In the aftermath of Sept. 11, 2001, the ITIC launched a research program on tools to analyze data called Knowledge, Discovery and Dissemination (KDD). It allocated $8 million per year to the program that concerns the entire American intelligence community. Starting from this year, ITIC is intent on seeing the KDD program focus more specifically on technologies allowing for real cooperation between different agencies through the use of shared data bases. ITIC answers directly to the CIA's Science and Technology directorate, as does the In-Q-Tel Interface Center (QIC), a unit that dovetails investment of the CIA's venture capital fund In-Q-Tel. However, ITIC and QIC don't operate in similar fashion.

In-Q-Tel invests mainly in companies developing information processing technologies (it answers to the CIA's Office of Advanced Information Technologies). For its part, ITIC chiefly subsidizes university labs and government agencies even if it sometimes pumps money into private companies such as LC Technologies (for its computer-controlled Eyetracking system in moving cars).

In addition to KDD, ITIC coordinates and finances research in a wide range of fields: nanotechnolgies (nanobatteries, miniaturization of sensors); biometrics; robotics, forecasting systems; fight against biological weapons; exploiting tera waves (a part of the electromagnetic field between short waves and infrared waves that can enable a user to "look through walls" to detect explosives and mines) and the like.